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Thursday, July 4, 2013

Pemphigoid gestationis

It is also called herpes gestationis. One of the pregnancy specific dermatoses and incidence is 1 in 3000 to 1 in 60000. Commonly occur in 2nd and 3rd trimester. Howevever can appear in 1st trimester and even in puerperium. It may resolve spontaneously within weeks or may prolonged up to year.
Started to occur in periumbilical area and spread the trunk and limbs.Erythematous urticarial plaques appear. Vesicles and bullae are seen at the centre or periphery of plaques. Microscopically, perivascular inflammation and subepidermal blisters  are
seen.
May be associated with other autoimmune disease such as Grave's disease.
Can be treated with moderate/ strong topical steroid, systemic steroids and antihistamine.
There may be possible increase in IUGR and preterm labour.

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